Issue 36, 2025
From the journal:

Chemical Communications

A high-entropy coordination cage featuring an Au-porphyrin metalloligand for the photodynamic therapy of liver cancer†

Feng-Lin Cao,a   Ze-Sheng Zhang,a   Meng-Lin Dong,a   Ye Ning,a   Wen-Hua Zhang, ORCID logo *a   Yiming Mao*b  and  David J. Youngc  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
E-mail: whzhang@suda.edu.cn

b Department of Thoracic Surgery, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215028, China
E-mail: mym19850126@163.com

c James Watt School of Engineering, Glasgow University, University Avenue, Glasgow, UK

Abstract

We report a Pd-based hexagonal prismatic coordination cage of Pd-TMPP(Au) featuring a highly entropic ligand combination, viz. H2TMPP, TMPP(Pd), and TMPP(Au) metalloligands to yield double-arrow-shaped polycrystals. Pd-TMPP(Au) exhibits concentration-dependent cytotoxicity against hepatocellular carcinoma cell lines HuH-7, Hep-G2, and PLC/PRF/5, which is augmented by light irradiation.

Graphical abstract: A high-entropy coordination cage featuring an Au-porphyrin metalloligand for the photodynamic therapy of liver cancer

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Article information

DOI
https://doi.org/10.1039/D5CC00750J
Article type
Communication
Submitted
14 Feb 2025
Accepted
01 Apr 2025
First published
02 Apr 2025

Chem. Commun., 2025,61, 6663-6666

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A high-entropy coordination cage featuring an Au-porphyrin metalloligand for the photodynamic therapy of liver cancer

F. Cao, Z. Zhang, M. Dong, Y. Ning, W. Zhang, Y. Mao and D. J. Young, Chem. Commun., 2025, 61, 6663 DOI: 10.1039/D5CC00750J

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