A sulfonated supramolecular host based on pillar[5]arene for succinylcholine-induced neuromuscular blockade reversal

Abstract

A per-sulfonated pillar[5]arene (SP[5]A) is designed as a reversal agent to reverse neuromuscular blockade induced by succinylcholine (Sch) via host–guest recognition. SP[5]A can rapidly and specifically recognize and encapsulate Sch in vivo for elimination with a binding affinity as high as 10⁵ M⁻¹. SP[5]A mitigates Sch-induced adverse reactions including hyperkalemia, arrhythmias, and rhabdomyolysis.