Electrochemical debrominative hydrogenation/deuteration of 2-bromo-N-arylacetamides

Abstract

Herein, we report a facile and efficient electro-reductive debrominative hydrogenation/deuteration of 2-bromo-N-aryl acetamides using H₂O/D₂O as an economical source of hydrogen/deuterium at room temperature. The reactions proceeded efficiently via C–Br bond activation, enabling facile synthesis of a range of N-substituted amides in moderate to high yields with broad functional group compatibility.