From the journal:

Chemical Communications

Construction of polymethine chain-modified pentamethylene cyanine dyes for G-quadruplex imaging in live cells†

Li Guan, ORCID logo *a   Jun Li,a   Yanyan Zhou,a   Anyang Li, ORCID logo c   Lili Yin,*b   Wenhui Guana  and  Yile Fu*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Xi'an University of Architecture and Technology, Xi’an, P. R. China
E-mail: guanli0317@163.com

b International Medical Department, The Second Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian, P. R. China

c Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, National Demonstration Center for Experimental Chemistry Education, College of Chemistry and Materials Science, Northwest University, Xi’an, P. R. China

Abstract

Here, a supramolecular strategy that relies on the G-quadruplex DNA recognition-driven disaggregation of pentamethylene cyanine Cy5-ph-H aggregates is outlined, which can turn on its fluorescence and be used to visualize G-quadruplex DNA in living cells and highly target mitochondria.

Graphical abstract: Construction of polymethine chain-modified pentamethylene cyanine dyes for G-quadruplex imaging in live cells

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Article information

DOI
https://doi.org/10.1039/D5CC00436E
Article type
Communication
Submitted
23 Jan 2025
Accepted
08 May 2025
First published
09 May 2025

Chem. Commun., 2025, Advance Article

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Construction of polymethine chain-modified pentamethylene cyanine dyes for G-quadruplex imaging in live cells

L. Guan, J. Li, Y. Zhou, A. Li, L. Yin, W. Guan and Y. Fu, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC00436E

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