Issue 18, 2025
From the journal:

Chemical Communications

Development of MhOR1 as a chemogenetic tool for odorant-mediated regulation of insulin release†

Hanbing Li,a   Gaojun Chen,a   Xiayan Lou,a   Changyi Hu,a   Ninghuai Zheng,a   Lian He*b  and  Yuanfa Yao*c  

* Corresponding authors

a Institute of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China

b Department of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, China
E-mail: hel3@sustech.edu.cn

c The Affiliated Huizhou Hospital, Guangzhou Medical University, Guangzhou, China
E-mail: yuanfayao@163.com

Abstract

Our study presents MhOR1, an odorant-responsive chemogenetic tool that facilitates calcium influx upon odorant activation. We optimized its membrane expression and demonstrated its ability to regulate insulin release in pancreatic β cells. Our results suggest that MhOR1 holds potential for gene regulation and therapeutic applications through odorant-triggered cellular activities.

Graphical abstract: Development of MhOR1 as a chemogenetic tool for odorant-mediated regulation of insulin release

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Article information

DOI
https://doi.org/10.1039/D5CC00304K
Article type
Communication
Submitted
17 Jan 2025
Accepted
04 Feb 2025
First published
04 Feb 2025

Chem. Commun., 2025,61, 3744-3747

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Development of MhOR1 as a chemogenetic tool for odorant-mediated regulation of insulin release

H. Li, G. Chen, X. Lou, C. Hu, N. Zheng, L. He and Y. Yao, Chem. Commun., 2025, 61, 3744 DOI: 10.1039/D5CC00304K

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