Issue 25, 2025
From the journal:

Chemical Communications

Direct and chemoselective transformation of cysteine to dehydroalanine on peptides†

Taiki Mori,a   Kazuki Sakatab  and  Seiji Shirakawa ORCID logo *a  

* Corresponding authors

a Institute of Integrated Science and Technology, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
E-mail: seijishirakawa@nagasaki-u.ac.jp

b Spiber Inc., 234-1 Mizukami, Kakuganji, Tsuruoka, Yamagata 997-0052, Japan

Abstract

A direct method for the preparation of peptides containing a dehydroalanine residue was developed through the chemoselective transformation of a cysteine residue in peptides, under the influence of cesium carbonate.

Graphical abstract: Direct and chemoselective transformation of cysteine to dehydroalanine on peptides

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Article information

DOI
https://doi.org/10.1039/D5CC00156K
Article type
Communication
Submitted
10 Jan 2025
Accepted
25 Feb 2025
First published
26 Feb 2025

Chem. Commun., 2025,61, 4800-4803

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Direct and chemoselective transformation of cysteine to dehydroalanine on peptides

T. Mori, K. Sakata and S. Shirakawa, Chem. Commun., 2025, 61, 4800 DOI: 10.1039/D5CC00156K

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