Elucidating cuproptosis-linked redox dynamics in Wilson's disease via a reversible ratiometric fluorescence strategy

Shunping Zang; Qingguo He; Yuyang Zeng; Yuyang Huang; Benhua Wang; Qing Liu; Xiangzhi Song

doi:10.1039/D4CC06677D

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Elucidating cuproptosis-linked redox dynamics in Wilson's disease via a reversible ratiometric fluorescence strategy†

Shunping Zang,‡^a Qingguo He,‡^a Yuyang Zeng,^a Yuyang Huang,^a Benhua Wang,

*^a Qing Liu*^a and Xiangzhi Song

*^a

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* Corresponding authors

^a College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, P. R. China

Abstract

The redox dynamics in cuproptosis and Wilson's disease (WD) were revealed using a reversible and ratiometric HOCl/GSH fluorescent probe, WD-Redox. It visualizes redox imbalances caused by excessive copper accumulation and monitors therapeutic effects of D-penicillamine. The probe's utility in studying oxidative stress in copper metabolism disorders and evaluating drug efficacy has been demonstrated.

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DOI: https://doi.org/10.1039/D4CC06677D
Article type: Communication
Submitted: 22 Dec 2024
Accepted: 06 Mar 2025
First published: 11 Mar 2025

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Chem. Commun., 2025,61, 5507-5510

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Elucidating cuproptosis-linked redox dynamics in Wilson's disease via a reversible ratiometric fluorescence strategy

S. Zang, Q. He, Y. Zeng, Y. Huang, B. Wang, Q. Liu and X. Song, Chem. Commun., 2025, 61, 5507 DOI: 10.1039/D4CC06677D

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Chemical Communications

Elucidating cuproptosis-linked redox dynamics in Wilson's disease via a reversible ratiometric fluorescence strategy†

Abstract

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Elucidating cuproptosis-linked redox dynamics in Wilson's disease via a reversible ratiometric fluorescence strategy

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