Recent advances in 4CzIPN-mediated functionalizations with acyl precursors: single and dual photocatalytic systems

Abstract

4CzIPN (1,2,3,5-tetrakis(carbazole-9-yl)-4,6-dicyanobenzene) has emerged as a key metal-free photocatalyst for sustainable organic synthesis. Due to its unique design enabling high photoluminescence quantum yield, thermally activated delayed fluorescence (TADF) and long excited state lifetime, 4CzIPN facilitates diverse reactions, such as C–C and C–X bond formation reactions, under mild reaction conditions. This review highlights its application in decarboxylation, acylation and cyclisation reactions involving α-keto acids, carboxylic acids and aldehydes in a single catalytic system, as well as the combination of a dual catalytic system with transition metals to enhance selectivity and scope. 4CzIPN contributes to the advancement of sustainable chemistry by enabling green, efficient and scalable reactions and this review covers studies published between 2020 and 2024.