An enzyme-free fluorescence biosensor for UO22+ detection using Y-shaped wheel-mediated triple walking as a signal amplifier

Ying Zeng; Yuyan Wang; Xiaoya Ren; Jun Qiu; Jiafeng Pan; Fei Yang

doi:10.1039/D4CC05748A

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An enzyme-free fluorescence biosensor for UO₂²⁺ detection using Y-shaped wheel-mediated triple walking as a signal amplifier†

Ying Zeng,^a Yuyan Wang,^a Xiaoya Ren,^a Jun Qiu,^b Jiafeng Pan*^a and Fei Yang

*^a

Author affiliations

* Corresponding authors

^a Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China

^b Hunan Children's Hospital, Hunan 410000, China

Abstract

Based on a Y-shaped wheel-mediated triple walker, an enzyme-free biosensor was reported for UO₂²⁺ detection. Due to the DNAzyme-driven mechanism, our walker was activated and produced a fluorescence signal for UO₂²⁺ assay. The sensor demonstrated ultra-sensitivity, good specificity and excellent accuracy, holding great promise for UO₂²⁺ sensing in complex water samples.

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Article information

DOI: https://doi.org/10.1039/D4CC05748A
Article type: Communication
Submitted: 29 Oct 2024
Accepted: 13 Dec 2024
First published: 10 Feb 2025

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Chem. Commun., 2025,61, 3756-3759

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An enzyme-free fluorescence biosensor for UO₂²⁺ detection using Y-shaped wheel-mediated triple walking as a signal amplifier

Y. Zeng, Y. Wang, X. Ren, J. Qiu, J. Pan and F. Yang, Chem. Commun., 2025, 61, 3756 DOI: 10.1039/D4CC05748A

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Chemical Communications