Circulating tumour DNA methylation: unlocking a new chapter in cancer diagnosis and treatment

Xingtong Zhan; Zhuo Jin; Shuhui Yang; Siqi Sun; Liying Zhang; Xinchen Zhou; Zhuo Zhang; Shuhan Dong; Yan Jiang; Limei Liu

doi:10.1039/D5AY00890E

Circulating tumour DNA methylation: unlocking a new chapter in cancer diagnosis and treatment

Xingtong Zhan,

^a Zhuo Jin,^a Shuhui Yang,^a Siqi Sun,^a Liying Zhang,^a Xinchen Zhou,^a Zhuo Zhang,^a Shuhan Dong,^a Yan Jiang^a and Limei Liu

*^a

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* Corresponding authors

^a Department of Experiment Center, School of Medical Technology, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province, China
E-mail: liulm74@163.com

Abstract

Circulating tumour DNA (ctDNA) methylation analysis, a noninvasive liquid biopsy technique, has shown great potential in cancer diagnosis and treatment. This article reviews the progress of research in ctDNA methylation detection. It summarises the advantages and potential of ctDNA methylation analysis, suggesting that it holds the key to unlocking new chapters in cancer diagnosis and therapy.

This article is part of the themed collection: Analytical Methods Review Articles 2025

Analytical Methods

Circulating tumour DNA methylation: unlocking a new chapter in cancer diagnosis and treatment

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