Advancing analytical chemistry with carbon quantum dots: a comprehensive review

Abstract

Carbon Quantum Dots (CQDs) have gained significant attention as versatile nanomaterials in analytical chemistry due to their strong fluorescence, high sensitivity, and biocompatibility features. This review explores the synthesis, functionalization, and broad applications of CQDs in various analytical domains, including bioimaging, diagnostics, and environmental monitoring. CQDs' unique properties, such as tunable emission and ease of surface modification, enhance their performance in fluorescence and electrochemical sensing. CQDs present emerging applications in single-cell analysis, point-of-care diagnostics, and food safety. Technological advancements in green synthesis and hybrid nanomaterial integration are paving the way for more sustainable, efficient, and scalable analytical tools. However, challenges related to reproducibility, stability, and large-scale production persist, highlighting the need for continued research. The present review provides a comprehensive overview of CQDs' impact, emphasizing their potential to transform analytical chemistry through innovative applications and future breakthroughs.