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Correction: Enhanced DNA release from disulfide-containing layered nanocomplexes by heparin-electrostatic competition
Zhenzhen
Chen
,
Yuling
He
,
Lifen
Zhang
* and
Yanfeng
Li
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China. E-mail: lfzhang@lzu.edu.cn; Fax: +86-0931-8912144; Tel: +86-0931-8912528
First published on 2nd January 2024
Abstract
Correction for ‘Enhanced DNA release from disulfide-containing layered nanocomplexes by heparin-electrostatic competition’ by Zhenzhen Chen et al., J. Mater. Chem. B, 2015, 3, 225–237, https://doi.org/10.1039/c4tb01113a.
The authors regret an error in Fig. 9E (DPS panel).
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| Fig. 9 (E) DPS-treated and control HEPES-treated tumors were achieved and Bmi-1 expression was detected using immunohistochemistry. | ||
During the manuscript preparation, the immunohistochemistry data in the Fig. 9E (DPS panel) was inconsistent with the raw data. The corrected Fig. 9E, containing updated DPS panel and unchanged HEPES panel, is shown here.
The updated DPS panel showed comparable expression levels of Bmi-1 to the primary DPSHA panel, both expressing lower Bmi-1 than HEPES and higher than DPSHA-HP. Here we also showed the HEPES panel of in vitro data. As shown in Fig. 8C, the Bmi-1 expression levels in the HEPES group (containing no shBmi-1) are much higher than the DPS group (containing shBmi-1), and the fold change of “DPS vs. DPSHA” (about 2–2.5) is smaller than “HEPES vs. DPS” (about 4–5) and “DPSHA vs. DPSHA-HP” (about 4) in vitro assay. In tumor tissues, the “DPS vs. DPSHA” difference is almost lost, whereas “HEPES vs. DPS” and “DPSHA vs. DPSHA-HP” are still maintained. These data highlight the excellent knockdown efficiency of DPSHA-HP even after long-term tumor initiation, consistent with our major conclusion.
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| Fig. 8 (C) containing HEPES panel: mRNA was extracted from HEPS, DPS, DPSHA and DPSHA–HP spheres, and Bmi-1 expression was detected using real-time PCR. | ||
An independent expert has viewed the corrected images and has concluded that they are consistent with the discussions and conclusions presented.
The authors sincerely apologize for any inconvenience caused.
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
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