Base- and metal-free visible-light driven site-selective α-C(sp3)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives

Abstract

A visible-light-mediated radical–radical cross-coupling reaction between hydroxamic acid derivatives and N-phenyl glycine derivatives for the preparation of unnatural amino acids and peptides under base- and metal-free conditions has been reported. The reaction features a broad substrate scope and good yields. Besides, biomolecule compatibility and gram-scale experiments were performed to prove the potential application value of this protocol.