Issue 48, 2024

A solvent-free and catalyst-free reaction of o-aminobenzophenone with aryl isothiocyanates: expedient access to congested 4-phenyl-4-hydroxyquinazolin-2-thione derivatives

Abstract

An efficient method to construct 4-phenyl-4-hydroxyquinazolin-2-thiones 3via solvent-free and catalyst-free addition of o-aminobenzophenone 1 with aryl isothiocyanates 2 under thermal conditions has been developed, providing new congested 4-phenyl-4-hydroxyquinazolin-2-thiones 3 in practically quantitative yields via simple purification by filtration/recrystallization. Extension of these conditions to o-aminoacetophenone 4 in place of o-aminobenzophenone 1 led to 4-methylenequinazoline-thione 5 as a result of a subsequent dehydration reaction.

Graphical abstract: A solvent-free and catalyst-free reaction of o-aminobenzophenone with aryl isothiocyanates: expedient access to congested 4-phenyl-4-hydroxyquinazolin-2-thione derivatives

Supplementary files

Article information

Article type
Communication
Submitted
05 Sep 2024
Accepted
25 Oct 2024
First published
28 Oct 2024

Org. Biomol. Chem., 2024,22, 9353-9356

A solvent-free and catalyst-free reaction of o-aminobenzophenone with aryl isothiocyanates: expedient access to congested 4-phenyl-4-hydroxyquinazolin-2-thione derivatives

L. A. Nguyen, T. T. T. Nguyen, Q. A. Ngo, P. Retailleau and T. B. Nguyen, Org. Biomol. Chem., 2024, 22, 9353 DOI: 10.1039/D4OB01452A

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