Issue 42, 2024

Molecular oxygen-promoted sustainable synthesis of functionalized quinolines using catalytic glucose-derived ionic liquids and copper

Abstract

An expedient one-pot sustainable synthesis of quinoline analogues was developed via protection-free chemo-selective oxidation of 2-aminobenzyl alcohols to form aldehydes, followed by annulation with various 1,3-dicarbonyl compounds or nitriles under mild reaction conditions in an acetonitrile–water medium using a copper catalyst and new hydrogen bond-rich glucose-based ionic liquids (GSILs). Overall, 40 functionalized quinolines were synthesized with up to 93% yields following significant green chemistry parameters. The developed GSILs were recyclable with not much decrease in the yields of the products and the reaction rate.

Graphical abstract: Molecular oxygen-promoted sustainable synthesis of functionalized quinolines using catalytic glucose-derived ionic liquids and copper

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Article information

Article type
Paper
Submitted
16 Aug 2024
Accepted
16 Sep 2024
First published
18 Sep 2024

Org. Biomol. Chem., 2024,22, 8472-8479

Molecular oxygen-promoted sustainable synthesis of functionalized quinolines using catalytic glucose-derived ionic liquids and copper

J. Jayakumar and S. Rajasekhara Reddy, Org. Biomol. Chem., 2024, 22, 8472 DOI: 10.1039/D4OB01354A

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