Highly efficient Ca2+ chelation activated by visible light

Nishal M. Egodawaththa; Olivia Rajhel; Jingxuan Ma; Charitha Guruge; Alec B. Pabarue; Emily Harris; Roberto Peverati; Nasri Nesnas

doi:10.1039/D4OB00951G

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Highly efficient Ca²⁺ chelation activated by visible light†

Nishal M. Egodawaththa,^a Olivia Rajhel,^a Jingxuan Ma,^a Charitha Guruge,^a Alec B. Pabarue,^a Emily Harris,^a Roberto Peverati^a and Nasri Nesnas

*^a

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* Corresponding authors

^a Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, Florida 32901, USA
E-mail: nesnas@fit.edu, enishalmaduj2020@my.fit.edu, orajhel2021@my.fit.edu, jma2014@my.fit.edu, cguruge2014@my.fit.edu, apabarue3@gatech.edu, eharris2020@my.fit.edu, rpeverati@fit.edu

Abstract

Calcium ion (Ca²⁺) control is an essential tool in neuronal research. Herein, we report three thiocoumarin-based, visible light-activated Ca²⁺ chelators with quantum yields of 0.39, 0.52, and 0.83. The chelators demonstrated an over 10⁵-fold increase in Ca²⁺ binding affinity upon irradiation. These chelators are efficiently triggered by biologically safer wavelengths, rendering them excellent candidates for use in neurological research and medicine.

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Article information

DOI: https://doi.org/10.1039/D4OB00951G
Article type: Paper
Submitted: 05 Jun 2024
Accepted: 12 Aug 2024
First published: 20 Aug 2024

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Org. Biomol. Chem., 2024,22, 7194-7202

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Highly efficient Ca²⁺ chelation activated by visible light

N. M. Egodawaththa, O. Rajhel, J. Ma, C. Guruge, A. B. Pabarue, E. Harris, R. Peverati and N. Nesnas, Org. Biomol. Chem., 2024, 22, 7194 DOI: 10.1039/D4OB00951G

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Organic & Biomolecular Chemistry