Visible-light-induced Fe(iii)-promoted reduction amidation of 1,4,2-dioxazol-5-one

Abstract

This method describes the iron-promoted amidation of dioxazolone under visible light to obtain aromatic/alkyl substituted amides. The nitrogen radicals formed during this process undergo hydrogen atom transfer (HAT) to form amides through the proton provided by HBpin. This reaction eliminates the need for external chemical oxidants and expensive photocatalysts, and exhibits compatibility with various aryl/alkyl substituted derivatives. This method has good prospects for application and development in organic synthesis and medicine.