New cationic linear N-chloramines based on N-t-butylamide: chemical synthesis and antibacterial application

Abstract

For the first time, we synthesized three types of cationic linear N-chloramines that do not use the popular 5,5-dimethyl hydantoin scaffold. The characterized N-chloramines displayed satisfactory bactericidal activity, and the long-chain analogues exerted greatly elevated biocidal efficacy due to “synergistic” antibacterial actions between the N–Cl moiety and long chain cationic center. Our study provides highly efficacious biocides as well as paving the way for producing novel N-chloramines that exclude toxic cyanide salts.