Avinash G.
Vishakantegowda
ab,
Dasom
Hwang
ac,
Prashant
Chakrasali
a,
Eunhye
Jung
a,
Joo-Youn
Lee
a,
Jin Soo
Shin
*a and
Young-Sik
Jung
*ab
aInfectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea. E-mail: jsshin@krict.re.kr; ysjung@krict.re.kr
bDepartment of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon 34113, Republic of Korea
cLaboratory of Veterinary Virology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea
First published on 12th June 2024
Correction for ‘Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents’ by Avinash G. Vishakantegowda et al., RSC Med. Chem., 2024, 15, 704–719, https://doi.org/10.1039/D3MD00630A.
Compd. | R | IC50b (μM) | |
---|---|---|---|
PI4KIIIα | PI4KIIIβ | ||
a All data were obtained from at least three independent experiments and the mean values of the standard deviations are listed. b IC50: inhibitory concentration (μM) for 50% inhibition of each kinase enzyme. | |||
1a | >10 | 0.094 ± 0.006 | |
2 | >10 | 2.5 ± 0.46 | |
3 | >10 | 0.019 ± 0.001 | |
4 | >10 | 0.03 ± 0.003 | |
5a | 2-Cl | >10 | 0.16 ± 0.034 |
5b | 3-Cl | >10 | 0.04 ± 0.003 |
5c | 4-Cl | >10 | 0.16 ± 0.035 |
5d | 3-F | >10 | 0.029 ± 0.006 |
5e | 3-Me | >10 | 0.021 ± 0.005 |
5f | 4-Me | >10 | 0.19 ± 0.073 |
5g | 2-OMe | >10 | 0.06 ± 0.006 |
5h | 3-OMe | >10 | 0.026 ± 0.004 |
5i | 4-OMe | >10 | 0.16 ± 0.07 |
5j | 3,5-(OMe)2 | >10 | 0.0161 ± 0.0025 |
5k | 3,4-(OMe)2 | >10 | 0.072 ± 0.005 |
5l | 3,4,5-(OMe)3 | >10 | 0.066 ± 0.00 |
6 | >10 | 0.014 ± 0.004 | |
7a | >10 | 0.027 ± 0.006 | |
7b | >10 | 1.9 ± 1.7 | |
7c | >10 | 0.51 ± 0.531 | |
7d | >10 | 0.027 ± 0.014 | |
7e | >10 | 0.016 ± 0.005 | |
7f | >10 | 0.0158 ± 0.0031 | |
Pleconaril | >10 | >10 | |
Rupintrivir | >10 | >10 | |
Enviroxime | >10 | 0.064 ± 0.01 |
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
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