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Correction: Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents

Avinash G. Vishakantegowda ab, Dasom Hwang ac, Prashant Chakrasali a, Eunhye Jung a, Joo-Youn Lee a, Jin Soo Shin *a and Young-Sik Jung *ab
aInfectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea. E-mail: jsshin@krict.re.kr; ysjung@krict.re.kr
bDepartment of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon 34113, Republic of Korea
cLaboratory of Veterinary Virology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea

Received 21st May 2024 , Accepted 21st May 2024

First published on 12th June 2024


Abstract

Correction for ‘Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents’ by Avinash G. Vishakantegowda et al., RSC Med. Chem., 2024, 15, 704–719, https://doi.org/10.1039/D3MD00630A.


There were two typographical errors in Table 4 in rows 19 and 21 and a column alignment error for the PI4KIIIβ column. Table 4 should read as follows:
Table 4 Inhibitory effect of N-(4-methyl-5-arylthiazol)-2-amide derivatives (1a–7f)a against PI4KIIIα and PI4KIIIβ
Compd. R IC50b (μM)
PI4KIIIα PI4KIIIβ
a All data were obtained from at least three independent experiments and the mean values of the standard deviations are listed. b IC50: inhibitory concentration (μM) for 50% inhibition of each kinase enzyme.
1a >10 0.094 ± 0.006
2 >10 2.5 ± 0.46
3 >10 0.019 ± 0.001
4 >10 0.03 ± 0.003
5a 2-Cl >10 0.16 ± 0.034
5b 3-Cl >10 0.04 ± 0.003
5c 4-Cl >10 0.16 ± 0.035
5d 3-F >10 0.029 ± 0.006
5e 3-Me >10 0.021 ± 0.005
5f 4-Me >10 0.19 ± 0.073
5g 2-OMe >10 0.06 ± 0.006
5h 3-OMe >10 0.026 ± 0.004
5i 4-OMe >10 0.16 ± 0.07
5j 3,5-(OMe)2 >10 0.0161 ± 0.0025
5k 3,4-(OMe)2 >10 0.072 ± 0.005
5l 3,4,5-(OMe)3 >10 0.066 ± 0.00
6 >10 0.014 ± 0.004
7a >10 0.027 ± 0.006
7b >10 1.9 ± 1.7
7c >10 0.51 ± 0.531
7d >10 0.027 ± 0.014
7e >10 0.016 ± 0.005
7f >10 0.0158 ± 0.0031
Pleconaril >10 >10
Rupintrivir >10 >10
Enviroxime >10 0.064 ± 0.01


The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


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