A half-sandwich Ru(II)-p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells.

Yin-Hsuan Sun; Huey-Ling  You; Manmath Narwane; Ru Xin Koi; Chai-Lin Kao; Shyng-Shiou F. Yuan; Wei-Ting Liao; Tsai-Te Lu; Sodio C. N. Hsu

doi:10.1039/D4DT01012D

View PDF Version

DOI: 10.1039/D4DT01012D (Paper) Dalton Trans., 2024, Accepted Manuscript

A half-sandwich Ru(II)-p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells.

(Note: The full text of this document is currently only available in the PDF Version )

Yin-Hsuan Sun , Huey-Ling You , Manmath Narwane , Ru Xin Koi , Chai-Lin Kao , Shyng-Shiou F. Yuan , Wei-Ting Liao , Tsai-Te Lu and Sodio C. N. Hsu

Received 6th April 2024 , Accepted 4th June 2024

First published on 10th June 2024

Abstract

The Ru(II)-nitrite complex, Ru4, is explored to release nitric oxide (NO) under acidic conditions and selectively induce a cytotoxic effect towards SK-MEL-28 cisplatin-resistant malignant melanoma cells. These findings suggest that targeting the tumor-associated pHe level could be an effective strategy for the drug function of Ru(II)-nitrite compounds.