Detecting carcinoembryonic antigen based on the aggregation-induced emission enhancement effect

Yanjun Lu; Mengqi Wang; Yiwen Yang; Qiukai Tang; Yanbo Zeng; Hailong Wang; Lijie Zhang; Chengrui Pan; Changkun Hu; Zhuowei Fu; Lei Li

doi:10.1039/D4CC04544K

Detecting carcinoembryonic antigen based on the aggregation-induced emission enhancement effect†

Yanjun Lu,^a Mengqi Wang,^a Yiwen Yang,

*^a Qiukai Tang,^b Yanbo Zeng,^a Hailong Wang,^a Lijie Zhang,^a Chengrui Pan,^a Changkun Hu,^a Zhuowei Fu^a and Lei Li*^a

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* Corresponding authors

^a Jiaxing Key Laboratory of Molecular Recognition and Sensing, College of Biological, Chemical Sciences and Engineering, Jiaxing University, Zhejiang, China
E-mail: yangyiwen@mail.zjxu.edu.cn, lei.li@mail.zjxu.edu.cn

^b Clinical Laboratory, Zhejiang Sian International Hospital, Jiaxing 314031, Zhejiang, China

Abstract

In this study, a novel label-free fluorescent aptasensor with an aggregation-induced emission enhancement effect was developed and applied for the detection of carcinoembryonic antigen (CEA). The sensor has a simple detection mechanism, easy operation, high sensitivity (with low limit of detection of 1 pg mL⁻¹), good selectivity, and wide linear range (0.003–10 ng mL⁻¹). In addition, it can be directly applied for the determination of CEA in human serum.

Chemical Communications

Detecting carcinoembryonic antigen based on the aggregation-induced emission enhancement effect†

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Detecting carcinoembryonic antigen based on the aggregation-induced emission enhancement effect

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