Issue 64, 2024

Deoxygenative alkynylation of amides via C[double bond, length as m-dash]O bond cleavage

Abstract

A novel deoxygenative alkynylation of amides promoted by a synergistic action of a divalent rare-earth element and a transition metal has been developed. In this method, α-alkynyl substituted amines are synthesized from unactivated amides and alkynes in a single transformation. Broad substrate scope and excellent selectivity for C[double bond, length as m-dash]O cleavage has been demonstrated. This approach represents a general method for the construction of versatile α-alkynyl substituted amines from unactivated amide bonds.

Graphical abstract: Deoxygenative alkynylation of amides via C [[double bond, length as m-dash]] O bond cleavage

Supplementary files

Article information

Article type
Communication
Submitted
13 May 2024
Accepted
10 Jul 2024
First published
11 Jul 2024

Chem. Commun., 2024,60, 8454-8457

Deoxygenative alkynylation of amides via C[double bond, length as m-dash]O bond cleavage

L. Chen, W. Zhou, J. Zhang, Y. Ding, M. Szostak and C. Liu, Chem. Commun., 2024, 60, 8454 DOI: 10.1039/D4CC02316A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements