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Gold(I)-catalyzed cycloisomerization of alcohol or amine tethered-vinylidenecyclopropanes providing access to morpholine, piperazine or oxazepane derivatives: a carbene versus non-carbene process

Jun-Sheng Wei a, Song Yang a, Yin Wei b, Sima Shamsaddinimotlagh c, Hossein Tavakol *c and Min Shi *ab
aKey Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, People's Republic of China
bState Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. E-mail: mshi@sioc.ac.cn
cDepartment of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran. E-mail: h_tavakol@cc.iut.ac.ir

Received 19th January 2023 , Accepted 24th February 2023

First published on 27th February 2023


Abstract

A gold(I)-catalyzed intramolecular cyclization of alcohol or amine tethered-vinylidenecyclopropanes via a carbene or non-carbene process was developed to afford functionalized morpholines, piperazines and oxazepanes in good yields with a broad scope and excellent functional group tolerance under mild conditions. The steric bulkiness or chain length can modulate the reaction pathway. Substrates with a less sterically hindered group located at the allene moiety afford morpholines or piperazines containing an alkylidenecyclopropane via the non-carbene process, while sterically bulky ones give morpholines or piperazines containing a cyclobutene unit through the carbene process. Moreover, extending the carbon chain length of vinylidenecyclopropane enables the formation of seven-membered oxazepane via the carbene process. The synthetic utility of this protocol was also highlighted by its gram-scale synthesis and various transformations of the cyclization products.


Morpholine, piperazine and oxazepane derivatives have gained extensive attention due to their positive physicochemical, metabolic and biological properties.1 They are biologically active nitrogen-containing heterocycles involved in a variety of natural products and pharmaceuticals, such as the antibiotic drug finafloxacin,2 antianginal drug trimetazidine,3 antidepressant agents reboxetine4 and befuraline,5 dopamine D4 receptor ligands,6 noradrenaline reuptake inhibitors7 and so on (Fig. 1). Although numerous methodologies have been established for the synthesis of these useful scaffolds,8 the construction of functionalized morpholine, piperazine or oxazepane derivatives still remains challenging.
image file: d3qo00085k-f1.tif
Fig. 1 Selected biologically active compounds containing morpholine, piperazine and 1,4-oxazepane skeletons.

Recently, gold(I)-catalyzed nucleophilic additions to C–C multiple bonds as a popular research branch of gold chemistry have made significant progress.9 Over the past two decades, considerable advancements have been made in gold(I)-catalyzed addition of X–H (X = O, N, C) bonds to unsaturated carbon–carbon bonds of olefins,10 alkynes11 and allenes.12 For instance, Widenhoefer et al.10a reported the first example of gold(I)-catalyzed intramolecular hydroamination of unactivated alkenes, efficiently affording various tetrahydropyrrole and hexahydropiperidine skeletons (Scheme 1a). Later, Yamamoto et al.12a reported the gold(I)-catalyzed intermolecular hydroamination between allenes and morpholine. The appropriate steric environment around gold catalysts plays a pivotal role in carrying out such aliphatic hydroamination. In addition, different from monosubstituted allenes (Scheme 1b), 1,3-disubstituted allenes usually gave a regioisomeric mixture and its ratio also depends on the steric effects (Scheme 1c). Moreover, an analogous cyclization reaction of alkynes has also been developed by Plé's group recently,11a giving N- and O-spirocycles in good to excellent yields (Scheme 1d).


image file: d3qo00085k-s1.tif
Scheme 1 Previous examples of gold(I)-catalyzed nucleophilic additions to C–C multiple bonds.

In the meantime, it should be mentioned that catalytic transformations involving gold carbenes as key intermediates are also considered as some of the most important aspects of homogeneous gold catalysis.13 To enrich the chemistry of gold carbene, a gold(I)-catalyzed cycloisomerization or allyl transfer of vinylidenecyclopropane-ene derivatives via controllable carbene or non-carbene processes has been explored in our laboratory,14 providing a new synthetic route for the construction of O-bearing heterocyclic scaffolds containing a fused tricyclic system and fused five- and six-membered ring systems. Substituents adjacent to the oxygen atom on the aryl groups could switch the reaction mode (Scheme 2a).


image file: d3qo00085k-s2.tif
Scheme 2 Our previous work of gold(I)-catalyzed cycloisomerization of vinylidenecyclopropane-enes via a carbene or non-carbene process and this work.

Therefore, vinylidenecyclopropanes (VDCPs) can be realized as excellent candidates for gold(I)-catalyzed cycloisomerization due to their multiple reaction sites.14,15 During our ongoing efforts on gold-catalyzed cycloisomerization of VDCPs, we subsequently designed and synthesized a series of VDCPs tethered with an alcohol or amine moiety to explore their reaction outcomes in gold(I)-catalyzed intramolecular cyclization (Scheme 2b, this work). Interestingly, we found that the cyclization could proceed through a carbene or a non-carbene process as well depending on the substrate's steric effect or the connected carbon chain length, affording various morpholine, piperazine or oxazepane derivatives in good yields under mild conditions. Herein, we wish to report the details in this context.

At the beginning of our investigation, VDCP 1a was selected as the model substrate to optimize the reaction conditions of this gold(I)-catalyzed intramolecular cyclization. As shown in Table 1, a series of gold catalysts have been screened using AgNTf2 as a silver salt additive and a pre-prepared JohnPhosAu(MeCN)SbF6 complex upon heating in chlorobenzene at 90 °C (Table 1, entries 1–8), and it was found that the product 2a was obtained in poor to moderate yields with complete consumption of substrate 1a, and XphosAuCl was identified as the best gold(I) catalyst in this reaction, affording 2a in 43% yield. Lowering the reaction temperature to 50 °C gave 2a in 60% yield (Table 1, entry 9) and then, we found that by carrying out the reaction at room temperature and prolonging the reaction time, the yield of 2a could be improved to 76% (Table 1, entry 10). The examination of the solvent effect with various commonly used solvents revealed that THF was the best solvent, giving 2a in 95% NMR yield along with 87% isolated yield (Table 1, entries 11–16). During the screening of solvents, it is surmised that the use of acetonitrile as the solvent resulted in essentially complete recovery of the starting material without observing the formation of the product presumably due to its coordination with the monovalent gold(I) catalyst (Table 1, entry 12). Notably, compared to the in situ generation of the cationic gold catalyst, using cationic gold catalyst XPhosAuNTf2 slightly reduced the yield of 2a (Table 1, entry 17). Furthermore, the effect of silver salts on the reaction outcome was explored, identifying that AgNTf2 led to a better result than other silver additives such as AgBF4, AgOTf, and AgSbF6 (Table 1, entries 18–20). No conversion was observed under the same conditions when the silver salt additive was replaced with NaBArF (Table 1, entry 21). As a consequence, alkylidenecyclopropane functionalized morpholine derivative 2a was obtained in 87% isolated yield with excellent regioselectivity using 5 mol% XPhosAuCl as the catalyst and 5 mol% AgNTf2 as the silver salt additive in THF at room temperature under an ambient atmosphere, which serve as the optimal conditions for the production of 2a. The control experiments illustrated that silver salts such as AgNTf2, Brønsted acid HNTf2, and XPhosAuCl did not catalyze the reaction at all, indicating that this cyclization is indeed catalyzed by the gold(I) complex (see S8 in the ESI). The crystal structure of 2a was unequivocally determined by X-ray diffraction as shown in Table 1, and the ORTEP drawing and its CIF data are presented in the ESI.

Table 1 Optimization of the reaction conditions for the synthesis of 2a

image file: d3qo00085k-u1.tif

Entrya Catalyst Time (h) Solvent Temp. (°C) Yieldb (%)
a The reaction scale is 0.1 mmol of 1a in untreated solvent (0.04 M). b Yield was determined from 1H NMR spectroscopic data using 1,3,5-trimethoxybenzene as an internal standard. c Isolated yield.
1 IPrAuCl, AgNTf2 12 PhCl 90 Trace
2 (4-CF3Ph)3PAuCl, AgNT2 12 PhCl 90 Trace
3 iPr3PAuCl, AgNTf2 12 PhCl 90 Trace
4 JohnPhosAuCl, AgNTf2 12 PhCl 90 11
5 PPh3AuCl, AgNTf2 12 PhCl 90 35
6 t Bu3PAuCl, AgNTf2 12 PhCl 90 12
7 JohnPhosAu(MeCN)SbF6 12 PhCl 90 38
8 XphosAuCl, AgNTf2 12 PhCl 90 43
9 XphosAuCl, AgNTf2 12 PhCl 50 60
10 XphosAuCl, AgNTf2 16 PhCl rt 76
11 XphosAuCl, AgNTf2 16 1,4-Dioxane rt 54
12 XphosAuCl, AgNTf2 16 CH3CN rt Trace
13 XphosAuCl, AgNTf2 16 DCE rt 40
14 XphosAuCl, AgNTf2 16 THF rt 95 (87)c
15 XphosAuCl, AgNTf2 16 DCM rt 46
16 XphosAuCl, AgNTf2 16 Toluene rt 68
17 XphosAuNTf2 16 THF rt 82
18 XphosAuCl, AgBF4 16 THF rt 50
19 XphosAuCl, AgOTf 16 THF rt 83
20 XphosAuCl, AgSbF6 16 THF rt 86
21 XphosAuCl, NaBArF 16 THF rt Trace


Next, we synthesized a variety of alcohol or amine tethered vinylidenecyclopropanes with different R groups located at allene moieties to explore the generality of this cyclization under the optimal conditions and the results are shown in Scheme 3. For alcohol tethered VDCPs 1b–1g, in which the R group was a linear alkyl substituent, an alkyl chain with a terminal protected aldehyde group, a homoallyl group or a benzyl group, the reaction was tolerated, affording the corresponding products 2b–2g in 58–87% yields along with a trace amount of inseparable cyclized compound 2′ derived from a gold–carbene induced cyclization. Remarkably, in the case of VDCP 1h bearing a cyclopropane at the allene moiety, the desired product 2h was formed in 74% yield as a single isomer perhaps due to the less steric hindrance of the cyclopropyl ring. Besides N-Ts protected VCDPs, N-phenylsulfonyl protected substrate 1i and N-Bs protected substrate 1j also performed very well, affording the desired products 2i and 2j in 98% and 87% yields, respectively. Substrates 1k and 1l connected by an oxygen atom or a carbon atom were also compatible, giving the corresponding products 2k and 2l in good yields ranging from 90% to 99% under the standard conditions. We were delighted to find that by replacing primary alcohol with a secondary alcohol, the substrate 1m delivered the desired product 2m in 92% yield as a single diastereoisomer and its stereochemical configuration was determined by 1H NMR NOESY spectroscopic analysis. Moreover, amine tethered vinylidenecyclopropanes 1n and 1o gave the desired functionalized piperazines 2n and 2o as single isomers in 77% and 85% yields, respectively, illustrating that this reaction has excellent functional group tolerance. Interestingly, the use of VDCP 1p as the substrate, which had a cyclobutane at the allene moiety, resulted in an inseparable mixture of 2p and 2p′, which contains a cyclobutene moiety, in an 8[thin space (1/6-em)]:[thin space (1/6-em)]5 ratio as determined by 1H NMR analysis presumably due to its steric effect. Notably, when replacing the benzylamine unit with a tosylated amine group such as VDCP 1z, no corresponding product could be obtained, perhaps due to its weaker nucleophilicity. In addition, aryl-substituted VDCPs 1aa–1ac were not suitable substrates for this gold-catalyzed transformation, presumably because the aryl substituents on the allene moiety make them difficult to polarize by cationic gold species in our reaction system. Substrate 1ad also failed to give the corresponding products under the standard conditions.


image file: d3qo00085k-s3.tif
Scheme 3 Substrate scope for the non-carbene process. Unless otherwise specified, all reactions were carried out using 1 (0.2 mmol), XPhosAuCl (5 mol%) and AgNTf2 (5 mol%) in THF (4.0 mL) at rt. Isolated yields. a[thin space (1/6-em)]Inseparable structural isomers of 2 and 2′ were formed and the ratio was determined on the basis of 1H NMR spectroscopic data.

In order to gain a better understanding of the reaction processes, several sterically bulky R groups were introduced into the substrates, and we found that all of them could give the cyclobutene containing cyclized products 2q′–2t′ as major products in 56–86% yields (Scheme 4). The crystal structure of 2q′ was unambiguously determined by X-ray diffraction. The ORTEP drawing is given in Scheme 4 and its CIF data are also summarized in the ESI. Particularly, different from VDCP 1p, cyclobutyl containing amine tethered vinylidenecyclopropane 1v furnished the desired product 2v′ as a sole product in 63% yield via a gold carbene process, indicating that the tethered nucleophile could also significantly affect the reaction pathway. To our surprise, further investigations revealed that our reaction system enables the formation of seven-membered 1,4-oxazepanes 2w′–2y′ in 67–88% yields as a sole product through a gold carbene process, indicating that the connected alkyl chain length of the substrate can modulate the reaction process.


image file: d3qo00085k-s4.tif
Scheme 4 Substrate scope for the carbene process. Unless otherwise specified, all reactions were carried out using 1 (0.2 mmol), XPhosAuCl (5 mol%) and AgNTf2 (5 mol%) in THF (4.0 mL) at rt. Isolated yields. a[thin space (1/6-em)]Inseparable structural isomers of 2′ and 2 were formed and the ratios were determined on the basis of 1H NMR spectroscopic data.

In order to elucidate the impact of substrate steric bulkiness on the selectivity of reaction pathways, substrates 1a and 1q were selected to investigate the energy differences of several gold-VDCP intermediates since the A-value16 of the methyl group is 1.8 kcal mol−1 and that of the isopropyl group is above 3.3 kcal mol−1.16d The relative free energies of several key intermediates are shown in Fig. 2 (for details, see S135 in the ESI). For substrate 1a, the gold catalyst activates the allene double-bond away from the cyclopropyl unit, which is favored by 0.96 kcal mol−1, suggesting that the non-carbene process is a dominant process for groups with less steric hindrance. For substrate 1q, the gold species activates the allene double-bond connected to the cyclopropyl unit, which is favored by 0.86 kcal mol−1, suggesting that the carbene process becomes a dominant process for groups with more steric hindrance. These results are in good agreement with our experimental findings (Schemes 3 and 4).


image file: d3qo00085k-f2.tif
Fig. 2 The relative free energies of key intermediates.

On the basis of the previous literature12e,14,17 and our above results, a plausible mechanism for the present cyclization reaction is depicted in Scheme 5. Under the conditions of gold(I) catalysis, substrate 1 can undergo two different reaction pathways (carbene and non-carbene processes) depending on the steric hindrance of the R groups or the connected alkyl chain length. As for the non-carbene process, the π-activation of the double bond in the allene moiety with the in situ generated gold(I) complex takes place to furnish intermediate A, which triggers a 6-exo-trig cyclization through intramolecular nucleophilic addition by the hydroxyl group onto the electrophilic carbon center to afford the alkenyl gold intermediate B. The protodeauration of intermediate B produces the corresponding morpholine derivative 2 along with the regeneration of the Au(I) catalytic species for the catalytic cycle. In this pathway, the sterically less hindered R groups in substrate 1 may result in a lower transition state energy barrier of 6-exo cyclization, giving the products 2 as the major ones. However, the carbene and non-carbene pathways are competing cyclization processes in these reactions. Sterically more bulky groups at substrate 1's allene moiety may delay the direct 6-exo cyclization since the transition energy barrier is quite high and the carbene process becomes the main cyclization process, affording products 2′ as the major ones. The same reason can be applied for the prolonged alkyl chain since the direct cyclization will become a slow process and the carbene process will dominate the reaction pathway. Thus, coordination of the gold(I) complex with vinylidenecyclopropane 1 bearing a sterically bulky group gives intermediate C, which initiates a ring expansion to afford the gold carbenoid intermediate D. The intramolecular nucleophilic attack of the hydroxyl group onto the electrophilic carbon center in intermediate D and release of a proton furnish intermediate E, which undergoes protodeauration to produce the cyclized product 2′ and regenerates the gold catalyst. More comprehensive investigations on the mechanistic manipulation of carbene and non-carbene processes and the related density functional theory (DFT) calculations will be published in due course.


image file: d3qo00085k-s5.tif
Scheme 5 Proposed reaction mechanisms.

To illustrate the synthetic utility of the obtained product, a gram-scale reaction of 1a, with 2.15 g (7.0 mmol), was performed and the reaction proceeded smoothly, delivering 1.8 g of 2a in 83% yield (Scheme 6). Then, a variety of transformations of 2a were conducted under different conditions (Scheme 6). Initially, treatment of 2a with HCl aqueous solution (4.0 M in dioxane) gave a chlorine-substituted vinylcyclopropane tethered alcohol, which could be further transformed to compound 3 in 78% overall yield in the presence of p-nitrobenzoyl chloride, and its structure has been clarified by X-ray diffraction as shown in Scheme 6. Its CIF data are also presented in the ESI. Next, iodine-substituted vinylcyclopropane tethered alcohol 4 was formed in 67% yield upon treating 2a with 1.0 equiv. of BF3·Et2O and 1.5 equiv. of Bu4NI in DCM at room temperature. Considering that product 2a contained an alkylidenecyclopropane subunit, treatment of 2a with Pd(OAc)2 and PhI(OAc)2 afforded the corresponding diacetoxylated product 5 in 42% yield through a palladium-catalyzed ring-opening reaction according to our previous work.18 Furthermore, epoxidation of 2a and 2q′ with m-CPBA in DCM successfully gave the desired epoxide 6 in 68% yield as a 3[thin space (1/6-em)]:[thin space (1/6-em)]1 diastereomeric mixture and the epoxide 7 in 94% yield as a single diastereomer (Scheme 6).


image file: d3qo00085k-s6.tif
Scheme 6 Gram-scale synthesis and transformations of the obtained products 2a and 2q′. All of the transformations were carried out using 0.1 mmol of 2a or 2q′. (a) XPhosAuCl (5 mol%), AgNTf2 (5 mol%), THF, rt. (b) (1) HCl (4 M in dioxane), 80 °C; (2) DMAP (0.2 equiv.), DIPEA (3.0 equiv.), p-nitrobenzoyl chloride (2.5 equiv.), DCM, 0 °C. (c) Bu4NI (1.5 equiv.), BF3·Et2O (1.0 equiv.), DCM, rt. (d) Pd(OAc)2 (0.1 equiv.), Bu4NI (1.0 equiv.), PhI(OAc)2 (3.0 equiv.), CH3CN, 60 °C. (e) m-CPBA (1.2 equiv.), DCM, rt. (f) m-CPBA (1.2 equiv.), DCM, rt.

Asymmetric variants of VDCPs 1a and 1q were also reacted with the chiral gold catalyst (R)-DTBM-SegPhosAuCl combined with AgNTf2 in DCM at room temperature (for details, see S8 in the ESI). As shown in Scheme 7, we found that treatment of 1a with 5 mol% (R)-DTBM-SegPhosAuCl and 10 mol% AgNTf2 afforded 2a in 78% yield along with 55% ee value. For substrate 1q, adding 5 mol% (R)-DTBM-SegPhosAuCl and 5 mol% AgNTf2 gave the desired product 2q′ in 88% yield along with 72% ee value.


image file: d3qo00085k-s7.tif
Scheme 7 Asymmetric versions of the two processes for the production of 2a and 2q′.

In conclusion, we have developed an efficient and novel synthetic protocol for the construction of morpholine, piperazine and oxazepane derivatives bearing an alkylidenecyclopropane or a cyclobutene moiety in good yields under mild conditions through a gold(I)-catalyzed intramolecular cycloisomerization of alcohol and amine tethered vinylidenecyclopropanes via a carbene or non-carbene process with a broad substrate scope. The steric bulkiness of the substituent at the allene moiety of vinylidenecyclopropanes and the chain length played key roles in the reaction pathway. In general, sterically bulky substituents and the prolonged alkyl chain prefer the gold(I)-catalyzed cyclization via a carbene process. In addition, a variety of transformations of the obtained product 2 have been performed to demonstrate their synthetic utility. Further investigations on the mechanistic paradigm of this gold(I)-catalyzed cyclization and the preparation of biologically active heterocycles are underway in our laboratory.

Author contributions

Shi, M. and Tavakol, H. directed the project and revised the manuscript. Wei, J. S., Shamsaddinimotlagh, S. and Yang, S. wrote the manuscript and carried out the reactions. Wei, Y. checked the spectroscopic data and revised the manuscript.

Conflicts of interest

There are no conflicts of interest to declare.

Acknowledgements

We are grateful for the financial support from the National Key R & D Program of China (2022YFC2303100), the National Natural Science Foundation of China (21372250, 21121062, 21302203, 20732008, 21772037, 21772226, 21861132014, 91956115, and 22171078), and the Fundamental Research Funds for the Central Universities 222201717003.

Notes and references

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Footnote

Electronic supplementary information (ESI) available: Experimental procedures and characterization data of new compounds. CCDC 1537103, 2178224, and 2178226. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d3qo00085k

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