An electrochemical tandem oxidative azidation and intramolecular cyclization strategy for the synthesis of quinoxaline derivatives

Abstract

An electrochemical-oxidation-induced intramolecular annulation for the synthesis of quinoxalines was developed under undivided electrolytic conditions. N-Aryl enamines and TMSN₃ as the starting materials could smoothly participate in the transformation to achieve the construction of two C–N bonds through tandem azidation and cyclic amination reactions. The reaction could be easily handled and avoided the use of transition metal catalysts as well as chemical oxidants, which makes it compatible with the sustainable development of green chemistry.