Issue 14, 2023

Electrochemically enabled decyanative C(sp3)–H oxygenation of N-cyanomethylamines to formamides

Abstract

Selective oxygenation of C(sp3)–H bonds adjacent to nitrogen atoms is a highly attractive strategy for synthesizing various formamide derivatives while preserving the substrate skeletons. Herein, an environmentally benign electrochemically enabled decyanative C(sp3)–H oxygenation of N-cyanomethylamines using H2O as a carbonyl oxygen atom source is described, leading to the synthesis of a large class of formamides in good to excellent yields with a broad substrate scope under metal- and oxidant-free conditions. This electrochemical technology highlights the facile incorporation of N-formyl into some important bioactive molecules.

Graphical abstract: Electrochemically enabled decyanative C(sp3)–H oxygenation of N-cyanomethylamines to formamides

Supplementary files

Article information

Article type
Communication
Submitted
26 Feb 2023
Accepted
16 Mar 2023
First published
16 Mar 2023

Org. Biomol. Chem., 2023,21, 2917-2921

Electrochemically enabled decyanative C(sp3)–H oxygenation of N-cyanomethylamines to formamides

M. Luo, W. Zhou, R. Yang, H. Ding, X. Song and Q. Xiao, Org. Biomol. Chem., 2023, 21, 2917 DOI: 10.1039/D3OB00313B

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