Electrochemically driven α-thiocarbamylation via a dehydrocoupling strategy of β-ketoesters with amines and CS₂

The development of atom- and step-economical methods for converting hazardous CS₂ into harmless chemicals is a challenging endeavor. Herein, we disclose a feasible strategy for the electrochemical dehydrogenative coupling of CS₂ and amines with β-ketoesters, which leads to dithiocarbamate intermediates in the presence of bases. In addition, inexpensive starting materials, broad substrate scope, and compatibility with natural product moieties make this efficient and sustainable reaction practical.