Continuous-flow dehydrative amidation between carboxylic acids and amines using modified mixed metal oxides as solid acid catalysts

Abstract

Dehydrative amidation reactions under continuous-flow conditions with solid acid catalysts were investigated. High performance molybdenum oxide-supported Zr–Sn mixed metal oxides were applied in reactions between aliphatic carboxylic acids and aliphatic amines, and the desired amides and cyclic imides were obtained in high yields with sufficient space–time yields.