Issue 16, 2023

Origin and remedy for HSQC artifacts in proton-detected INADEQUATE spectra

Abstract

NMR pulse sequences visualizing 1JCC and nJCC bond connectivity via an intermediate state of 13C–13C double-quantum coherence and 1H detection are an indispensable tool to solve small-molecule structures at the natural abundance level of 13C. A longstanding issue with these experiments set up to display 2D spectra with single-quantum frequencies is that in addition to the 1H–13C–13C correlations of interest, appearance of HSQC-type artifacts can complicate analysis and obscure JCC connectivities. The origin of these artifacts is described and remedies for their suppression are introduced. They include refocusing of 1JCH couplings prior to creation of 13C–13C double-quantum coherence, which is known to enhance sensitivity by reducing loss into zero-quantum coherence for pairs of two protonated 13C.

Graphical abstract: Origin and remedy for HSQC artifacts in proton-detected INADEQUATE spectra

Supplementary files

Article information

Article type
Communication
Submitted
10 Jan 2023
Accepted
28 Feb 2023
First published
01 Mar 2023

Phys. Chem. Chem. Phys., 2023,25, 11080-11084

Origin and remedy for HSQC artifacts in proton-detected INADEQUATE spectra

R. T. Williamson and O. W. Sørensen, Phys. Chem. Chem. Phys., 2023, 25, 11080 DOI: 10.1039/D3CP00142C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements