A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker

Hermann Neitz; Claudia Höbartner

doi:10.1039/D3CC03796G

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A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker†

Hermann Neitz

^a and Claudia Höbartner

*^ab

Author affiliations

* Corresponding authors

^a Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
E-mail: claudia.hoebartner@uni-wuerzburg.de

^b Center for Nanosystems Chemistry (CNC), University of Würzburg, Theodor-Boveri-Weg, 97074 Würzburg, Germany

Abstract

We report the fluorescent nucleoside ^ToldU and its application as a photoresponsive crosslinker in three different DNA architectures with enhanced fluorescence emission of the crosslinked products. The fluorogenic ^ToldU crosslinking reaction enables the assembly of DNA polymers in a hybridization chain reaction for the concentration-dependent detection of a specific DNA sequence.

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Article information

DOI: https://doi.org/10.1039/D3CC03796G
Article type: Communication
Submitted: 04 Aug 2023
Accepted: 13 Sep 2023
First published: 13 Sep 2023

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Chem. Commun., 2023,59, 12003-12006

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A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker

H. Neitz and C. Höbartner, Chem. Commun., 2023, 59, 12003 DOI: 10.1039/D3CC03796G

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Chemical Communications

A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker†

Abstract

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A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker

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