Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Ai-Ci Chan; Pei-Ya Shan; Men-Hsin Wu; Pin-Han Lin; Chang-Shun Tsai; Chia-Chien Hsu; Ting-Hsiang Chiu; Ting-Wei Hsu; Yi-Cheun Yeh; Yun-Ju Lai; Wei-Min Liu; Ling-Hsien Tu

doi:10.1039/D3CC03363E

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity†

Ai-Ci Chan,‡^a Pei-Ya Shan,‡^a Men-Hsin Wu,^a Pin-Han Lin,

^b Chang-Shun Tsai,^a Chia-Chien Hsu,

^a Ting-Hsiang Chiu,^d Ting-Wei Hsu,^c Yi-Cheun Yeh,

^d Yun-Ju Lai,*^c Wei-Min Liu

*^b and Ling-Hsien Tu

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan
E-mail: litu@gapps.ntnu.edu.tw

^b Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan
E-mail: 133797@mail.fju.edu.tw

^c Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan
E-mail: yunjulai@ntnu.edu.tw

^d Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan

Abstract

Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure–activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

Chemical Communications

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity†

Abstract

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Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

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