Ganglioside GM1 produces stable, short, and cytotoxic Aβ40 protofibrils

Abstract

Monosialoganglioside GM1-bound amyloid β-peptides have been found in patients’ brains exhibiting early pathological changes of Alzheimer's disease. Herein, we report the ability of non-micellar GM1 to modulate Aβ₄₀ aggregation resulting in the formation of stable, short, rod-like, and cytotoxic Aβ₄₀ protofibrils with the ability to potentiate both Aβ₄₀ and Aβ₄₂ aggregation.