Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and biodistribution†
Julie
Pineau, 
a
Luís M. P.
Lima,
b
Marie M.
Le Roy,
a
Séverine
Marionneau-Lambot,
c
Marie
Cordier,
d
Patricia
Le Saëc,
c
Jan Rijn
Zeevaart,
e
Cathryn H. S.
Driver,
e
Alain
Faivre-Chauvet,
c
Nathalie
Le Bris
*a
and
Raphaël
Tripier
*a
a
Luís M. P.
Lima,
b
Marie M.
Le Roy,
a
Séverine
Marionneau-Lambot,
c
Marie
Cordier,
d
Patricia
Le Saëc,
c
Jan Rijn
Zeevaart,
e
Cathryn H. S.
Driver,
e
Alain
Faivre-Chauvet,
c
Nathalie
Le Bris
*a
and
Raphaël
Tripier
*a
Abstract
Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64Cu-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.
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