Issue 22, 2023

Engineered exosomes for tissue regeneration: from biouptake, functionalization and biosafety to applications

Abstract

Exosomes are increasingly recognized as important effector molecules that regulate intercellular signaling pathways. Notably, certain types of exosomes can induce therapeutic responses, including cell proliferation, angiogenesis, and tissue repair. The use of exosomes in therapy is a hot spot in current research, especially in regenerative medicine. Despite the therapeutic potential, problems have hindered their success in clinical applications. These shortcomings include low concentration, poor targeting and limited loading capability. To fully realize their therapeutic potential, certain modifications are needed in native exosomes. In the present review, we summarize the exosome modification and functionalization strategies. In addition, we provide an overview of potential clinical applications and highlight the issues associated with the biosafety and biocompatibility of engineered exosomes in applications.

Graphical abstract: Engineered exosomes for tissue regeneration: from biouptake, functionalization and biosafety to applications

Article information

Article type
Review Article
Submitted
13 Jul 2023
Accepted
27 Sep 2023
First published
30 Sep 2023

Biomater. Sci., 2023,11, 7247-7267

Engineered exosomes for tissue regeneration: from biouptake, functionalization and biosafety to applications

M. Zhang, L. Wan, R. Li, X. Li, T. Zhu and H. Lu, Biomater. Sci., 2023, 11, 7247 DOI: 10.1039/D3BM01169K

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