Issue 17, 2023

Electron beam irradiation modified carboxymethyl chitin microsphere-based hemostatic materials with strong blood cell adsorption for hemorrhage control

Abstract

Timely control of coagulopathy bleeding can effectively reduce the probability of wound infection and mortality. However, it is still a challenge for microsphere hemostatic agents to achieve timely control of coagulopathy bleeding. In this work, the CCM-g-AA@DA hemostatic agent based on carboxymethyl chitin microspheres, CCM, was synthesized using electron beam irradiation-induced grafting polymerization of acrylic acid and coupling with dopamine. Irradiation grafting endowed the microspheres with excellent adsorption performance and a rough surface. The microspheres showed a strong affinity to blood cells, especially red blood cells. The maximum adsorption of red blood cells is up to approximately 100 times that of the original microspheres, the CCM. The introduction of dopamine increased the tissue adhesion of the microspheres. At the same time, the microspheres still possessed good blood compatibility and biodegradability. Furthermore, the CCM-g-AA@DA with Fe3+ achieved powerful procoagulant effects in the rat anticoagulant bleeding model. The bleeding time and blood loss were both reduced by about 90% compared with the blank group, which was superior to that of the commercially available collagen hemostatic agent Avitene™. In summary, the CCM-g-AA@DA hemostatic agent shows promising potential for bleeding control in individuals with coagulation disorders.

Graphical abstract: Electron beam irradiation modified carboxymethyl chitin microsphere-based hemostatic materials with strong blood cell adsorption for hemorrhage control

Supplementary files

Article information

Article type
Paper
Submitted
08 May 2023
Accepted
04 Jul 2023
First published
05 Jul 2023

Biomater. Sci., 2023,11, 5908-5917

Electron beam irradiation modified carboxymethyl chitin microsphere-based hemostatic materials with strong blood cell adsorption for hemorrhage control

F. Leng, T. Li, T. Li, C. Xie and X. Jiang, Biomater. Sci., 2023, 11, 5908 DOI: 10.1039/D3BM00787A

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