Promoting high T2 contrast in Dy-doped MSNs through Curie effects

Connor M. Ellis; Juan Pellico; Liam A. J. Young; Jack Miller; Jason J. Davis

doi:10.1039/D1TB01894A

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Promoting high T₂ contrast in Dy-doped MSNs through Curie effects†

Connor M. Ellis,

^a Juan Pellico,

^ab Liam A. J. Young,

^cd Jack Miller

^cde and Jason J. Davis

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Oxford, South Parks Road, Oxford, UK
E-mail: jason.davis@chem.ox.ac.uk
Fax: +44 (0)1865 272 690
Tel: +44 (0)1865 275 914

^b School of Biomedical Engineering & Imaging Sciences, King's College London, St. Thomas’ Hospital, London, UK

^c Department of Physiology, Anatomy & Genetics, University of Oxford, South Parks Road, Oxford, UK

^d Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Level 0, John Radcliffe Hospital, Oxford, UK

^e Department of Physics, Clarendon Laboratory, Parks Road, Oxford, UK

Abstract

Contrast agents retaining high relaxivities at ultrahigh magnetic fields underpin an enhanced image sensitivity within derived MRI scans. By varying the Dy³⁺ loading density inside a mesoporous silica architecture the dominant Curie effect can be effectively tuned so as to optimise T₂ contrast at magnetic fields as high as 11.7 T.

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Article information

DOI: https://doi.org/10.1039/D1TB01894A
Article type: Paper
Submitted: 30 Aug 2021
Accepted: 08 Dec 2021
First published: 09 Dec 2021

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J. Mater. Chem. B, 2022,10, 302-305

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Promoting high T₂ contrast in Dy-doped MSNs through Curie effects

C. M. Ellis, J. Pellico, L. A. J. Young, J. Miller and J. J. Davis, J. Mater. Chem. B, 2022, 10, 302 DOI: 10.1039/D1TB01894A

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Journal of Materials Chemistry B