Issue 8, 2022

Preparation of 3-aceta mido-5-acetylfuran from N-acetylglucosamine and chitin using biobased deep eutectic solvents as catalysts

Abstract

3-Acetamido-5-acetylfuran (3A5AF) is an important platform compound, possessing very promising application prospects. Herein, we propose a new approach to convert N-acetylglucosamine (NAG) and chitin to 3A5AF using biobased deep eutectic solvents (DESs) containing choline chloride and various organic acids or polyols. A comparison of catalytic capacity showed that a DES made with choline chloride/citric acid (CCCA) possesses the optimum catalytic properties, which lead to a maximum yield for 3A5AF of 47.1 mol% and 5.0 mol% from NAG and chitin, respectively, at 210 °C in N,N-dimethylacetamide solvent with CaCl2·2H2O as an additive. Moreover, CCCA showed excellent recyclability and retained over 63.6% of its original activity after five cycles of use. In addition, the 3A5AF product was obtained with 99.0% purity by simple extraction and crystallization. This research provided a new avenue for 3A5AF production from renewable chitin resources.

Graphical abstract: Preparation of 3-aceta mido-5-acetylfuran from N-acetylglucosamine and chitin using biobased deep eutectic solvents as catalysts

Supplementary files

Article information

Article type
Paper
Submitted
22 Mar 2022
Accepted
22 Apr 2022
First published
23 Apr 2022

React. Chem. Eng., 2022,7, 1742-1749

Preparation of 3-aceta mido-5-acetylfuran from N-acetylglucosamine and chitin using biobased deep eutectic solvents as catalysts

C. Wu, C. Wang, A. Zhang, K. Chen, F. Cao and P. Ouyang, React. Chem. Eng., 2022, 7, 1742 DOI: 10.1039/D2RE00118G

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