Issue 19, 2022
From the journal:

Organic Chemistry Frontiers

Palladium-catalyzed carbonylative synthesis of indole-3-carboxamides from 2-ethynylanilines and nitroarenes†

Jiangjie Zhang,‡a   Shangyuan Wang,‡a   Jian-Shu Wang,a   Jun Ying ORCID logo *a  and  Xiao-Feng Wu ORCID logo *bc  

* Corresponding authors

a Department of Chemistry, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China
E-mail: yingjun@zstu.edu.cn

b Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning, China
E-mail: xwu2020@dicp.ac.cn

c Leibniz-Institut für Katalyse e. V., Albert-Einstein-Straβe 29a, 18059 Rostock, Germany
E-mail: xiao-feng.wu@catalysis.de

Abstract

A palladium-catalyzed carbonylative cyclization of 2-ethynylanilines with nitroarenes has been developed for the rapid synthesis of indole-3-carboxamide skeletons. By using nitroarenes as the nitrogen source and Mo(CO)6 as the CO surrogate, the reaction proceeded smoothly to furnish various indole-3-carboxamide derivatives in moderate to high yields.

Graphical abstract: Palladium-catalyzed carbonylative synthesis of indole-3-carboxamides from 2-ethynylanilines and nitroarenes

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Article information

DOI
https://doi.org/10.1039/D2QO01065H
Article type
Research Article
Submitted
04 Jul 2022
Accepted
14 Aug 2022
First published
15 Aug 2022

Org. Chem. Front., 2022,9, 5219-5224

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Palladium-catalyzed carbonylative synthesis of indole-3-carboxamides from 2-ethynylanilines and nitroarenes

J. Zhang, S. Wang, J. Wang, J. Ying and X. Wu, Org. Chem. Front., 2022, 9, 5219 DOI: 10.1039/D2QO01065H

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