Issue 41, 2022

Progressive study on ruthenium catalysis for de(hydrogenative) alkylation and alkenylation using alcohols as a sustainable source

Abstract

At present, alcohols are considered sustainable starting materials that can be used in organic synthesis for various organic transformations and the preparation of commodity chemicals. Acceptorless dehydrogenation (AD) and borrowing hydrogen (BH) are two important methods for activating alcohols for alkenylation and alkylation. These approaches are sustainable because their process liberates water and in some cases (i.e., AD) molecular hydrogen as clean byproducts. Moreover, this area of research has attracted significant attention in the catalysis community, and various transition metals have been used to explore the same. Herein, in this review, we focus on the development of Ru-based catalyst systems for C-alkylation/alkenylation reactions via the AD or BH approach. This review also features a comparative study of the various Ru-catalysts used to optimize the reaction conditions. Furthermore, we extensively cover the outcomes of the mechanistic studies to describe the reaction pathways.

Graphical abstract: Progressive study on ruthenium catalysis for de(hydrogenative) alkylation and alkenylation using alcohols as a sustainable source

Article information

Article type
Review Article
Submitted
22 Jul 2022
Accepted
23 Sep 2022
First published
23 Sep 2022

Org. Biomol. Chem., 2022,20, 7998-8030

Progressive study on ruthenium catalysis for de(hydrogenative) alkylation and alkenylation using alcohols as a sustainable source

R. Sharma, A. Samanta, B. Sardar, M. Roy and D. Srimani, Org. Biomol. Chem., 2022, 20, 7998 DOI: 10.1039/D2OB01323A

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