Issue 34, 2022

Cu-catalyzed oxidative denitrogenation of 3-aminoindazoles for the synthesis of isoquinolinones

Abstract

A Cu-catalyzed oxidative dual arylation of active alkenes via the cleavage of two C–N bonds of 3-aminoindazoles is presented for constructing isoquinolinones. Importantly, 3-aminoindazoles are used as efficient arylating agents through a radical process. This method has a good substrate scope and functional group compatibility.

Graphical abstract: Cu-catalyzed oxidative denitrogenation of 3-aminoindazoles for the synthesis of isoquinolinones

Supplementary files

Article information

Article type
Paper
Submitted
06 Jul 2022
Accepted
05 Aug 2022
First published
08 Aug 2022

Org. Biomol. Chem., 2022,20, 6844-6853

Cu-catalyzed oxidative denitrogenation of 3-aminoindazoles for the synthesis of isoquinolinones

Y. Guo, P. Huang, B. Xiong, J. Fan and Y. Liu, Org. Biomol. Chem., 2022, 20, 6844 DOI: 10.1039/D2OB01207C

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