Radical spirocyclization of biaryl ynones for the construction of NO2-containing spiro[5.5]trienones

Abstract

While the radical spirocyclization of biaryl ynones for the construction of spiro[5.5]trienones has been widely explored, we report in this work on a new N-centered radical initiated spirocyclization of biaryl ynones under metal- and additive-free conditions. This approach features good functional group tolerance and pot-, atom-, and step-economy. This protocol affords a facile and green way for the construction of NO₂-containing spiro[5.5]trienones.