Hypervalent-iodine-mediated oxidation followed by the acetoxylation/tosylation of α-substituted benzylamines to obtain α-acyloxy/tosyloxy ketones

Abstract

An efficient and metal-free method has been developed for the sequential oxidation of α-alkylbenzylamines followed by acetoxylation or tosylation for the synthesis of α-acyloxy/tosyloxy ketones using hypervalent iodine(III). The employment of a simple starting material, broad substrate scope and operational simplicity are the key features of this protocol.