Electrochemical synthesis of carbamo(dithioperoxo)thioates through the dehydrogenation coupling of thiols and amines and the insertion of CS2

Abstract

A convenient and practical strategy was developed for the synthesis of carbamo(dithioperoxo)thioates through the simple dehydrogenation coupling of thiols and amines and the insertion of CS₂ under mild reaction conditions and in the absence of oxidizing reagents. This environmentally friendly electrosynthesis method has a broad substrate scope and can produce a series of bioactive compounds. This strategy is further employed in an electrochemical continuous flow reactor for the preparation of some antifilarial activity compounds, implying its potential application.