Issue 20, 2022

Catalyst-free benzylic C(sp3)–H cross-coupling with organotrifluoroborates enabled by electrochemistry

Abstract

Herein, we report a rare catalyst-free electrochemical cross-coupling of benzylic C–H bonds with organotrifluoroborates, which readily proceeds at room temperature and provides a unique protocol for forging C(sp3)–C(sp3), C(sp3)–C(sp2) and C(sp3)–C(sp) bonds. In particular, this work discloses the dual role of organotrifluoroborates serving both as a coupling partner and an electrolyte in C(sp3)–H functionalization.

Graphical abstract: Catalyst-free benzylic C(sp3)–H cross-coupling with organotrifluoroborates enabled by electrochemistry

Supplementary files

Article information

Article type
Communication
Submitted
10 Jun 2022
Accepted
12 Sep 2022
First published
12 Sep 2022

Green Chem., 2022,24, 7883-7888

Catalyst-free benzylic C(sp3)–H cross-coupling with organotrifluoroborates enabled by electrochemistry

C. Li, R. Ding, H. Guo, S. Xia, L. Shu, P. Wang and H. Li, Green Chem., 2022, 24, 7883 DOI: 10.1039/D2GC02204D

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