Ternary and quaternary cocrystals of 2,7-dihydroxynaphthalene: systematic design with a large synthon module

Abstract

Ternary and quaternary cocrystals of 2,7-dihydroxynaphthalene are synthesized with N-bases and polyaromatic hydrocarbons. Three different large synthons are observed depending on the nature of coformers and crystallization conditions. Among the three large synthons, a large synthon module (synthon C) appears repeatedly in most of the ternary cocrystals, showing its robustness. The same synthon is exploited further in the design of other higher-order cocrystals.