Herein, we report a three-component organophotoredox coupling of N-alkenyl amides with α-bromocarbonyls and various nucleophiles. This transition metal-free difunctionalization protocol installs sequential C–C and C–Y (Y = S/O/N) bonds in alkenes. This reaction works with terminal and internal alkenes containing both cyclic and acyclic amides via radical-polar crossover.
R. K. Dhungana, A. Granados, M. Sharique, J. Majhi and G. A. Molander, Chem. Commun., 2022, 58, 9556 DOI: 10.1039/D2CC04101D
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