A protein-conjugated photosensitizer with mitochondrial targeting ability was synthesized to enhance the therapeutic effects of PDT. The ROS produced by the photosensitizer under laser irradiation could effectively destroy key intracellular proteins and disrupt mitochondrial redox homeostasis, thereby causing mitochondrial dysfunction and irreversible cell death.
M. Shi, W. Pan, P. Gao, Y. Chen, K. Wang, N. Li and B. Tang, Chem. Commun., 2022, 58, 11729 DOI: 10.1039/D2CC03141H
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