Issue 23, 2022

Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro

Abstract

A series of specific and potent fluorescent ligands were developed for labelling and visualizing Kv7.2/7.3 based molecular rotation restriction. Probes 21b and 24a were found to be safe and convenient tools to detect and visualize Kv7.2/7.3 in live cells and mouse brain tissue.

Graphical abstract: Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro

Supplementary files

Article information

Article type
Communication
Submitted
19 Jan 2022
Accepted
20 Feb 2022
First published
21 Feb 2022

Chem. Commun., 2022,58, 3791-3794

Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro

Z. Qiao, S. Tang, J. Guan, Z. Yin, C. Zhu, Q. Zhou and L. Shao, Chem. Commun., 2022, 58, 3791 DOI: 10.1039/D2CC00372D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements