Issue 67, 2021
From the journal:

Chemical Communications

Iridium(iii) complexes as mitochondrial topoisomerase inhibitors against cisplatin-resistant cancer cells†

Liting He,a   Kai Xiong,a   Lili Wang,a   Ruilin Guan,*a   Yu Chen, ORCID logo *a   Liangnian Jia  and  Hui Chao ORCID logo *a  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, P. R. China
E-mail: ceschh@mail.sysu.edu.cn, chenyu63@mail.sysu.edu.cn, guanrlin@hotmail.com

Abstract

Herein, we developed the first metal-based mitochondrial topoisomerase inhibitors to achieve an effective therapeutic outcome for the therapy of cisplatin-resistant tumour cells.

Graphical abstract: Iridium(iii) complexes as mitochondrial topoisomerase inhibitors against cisplatin-resistant cancer cells

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Article information

DOI
https://doi.org/10.1039/D1CC02178H
Article type
Communication
Submitted
24 Apr 2021
Accepted
21 Jul 2021
First published
21 Jul 2021

Chem. Commun., 2021,57, 8308-8311

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Iridium(III) complexes as mitochondrial topoisomerase inhibitors against cisplatin-resistant cancer cells

L. He, K. Xiong, L. Wang, R. Guan, Y. Chen, L. Ji and H. Chao, Chem. Commun., 2021, 57, 8308 DOI: 10.1039/D1CC02178H

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