Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

Rui Zhang; Liang Cheng; Ziliang Dong; Linqian Hou; Shaohua Zhang; Zhouqi Meng; Oshra Betzer; Yihua Wang; Rachela Popovtzer; Zhuang Liu

doi:10.1039/D0MH00193G

Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief†

Rui Zhang,^a Liang Cheng,

*^a Ziliang Dong,^a Linqian Hou,^a Shaohua Zhang,^a Zhouqi Meng,^a Oshra Betzer,^b Yihua Wang,^a Rachela Popovtzer

^b and Zhuang Liu

*^a

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* Corresponding authors

^a Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, China
E-mail: lcheng2@suda.edu.cn, zliu@suda.edu.cn

^b The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 52900, Israel

Abstract

Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe–curcumin CPNs (Fe–Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.

Materials Horizons

Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief†

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Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

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