Transition metal catalysed direct construction of 2-pyridone scaffolds through C–H bond functionalizations

Abstract

Substituted 2-pyridone is one of the most frequent scaffolds among nitrogen-containing bioactive natural products, pharmaceuticals and organic materials. Besides the classical syntheses to construct this class of molecules, retrosynthetically more straightforward approaches based on transition metal catalysed C–H bond functionalizations have been explored recently. In this review, we have summarized the recent progress in the direct transition metal catalysed construction of substituted 2-pyridone scaffolds via site-selective C–H bond functionalizations.